RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
TAP1
RNA ID
RNA Type
mRNA
Alteration Pattern
down regulation
Species
homo sapiens
Detection Methods
Data compilation; Statistical analysis etc.
Target
NA
Pathway
NA
PubMed ID
Title
Transcriptome of Cultured Lung Fibroblasts in Idiopathic Pulmonary Fibrosis: Meta-Analysis of Publically Available Microarray Datasets Reveals Repression of Inflammation and Immunity Pathways
Year
2016
Function
"Consistent with repression of processes involved in the immune/inflammatory response, the downregulated list was enriched with genes bearing binding sites for the Interferon Response Factor (IRF) transcription factor (11 genes out of 158 in the annotation: DHX58, IDO1, IFI44, CASP1, PSMB9, PSMB10, SLC15A3, UBA7, ASPA, SLC12A7, TAP1, p = 4.2E-6) And the Interferon Consensus Sequence Binding Protein (ICSBP) transcription factor (9 genes out of 203 in the annotation : IDO1, IFI44, PSMB9, SLC15A3, IFI35, UBA7, ASPA, SLC12A7, TAP1; P = 3.2E-3)."